We tailor each of our therapies
to the biology of the disease,
using a modular platform that fine-tunes expression, duration, and delivery to meet the specific demands of each condition.

Thanks to advances in RNA technology, we can now engineer medicines that produce therapeutic proteins within targeted cells and tissues. Our RNA platform reprograms immune cells directly inside the body, in vivo, enabling precise and flexible treatment at the source of disease — without the complexity of ex vivo cell therapies.

Precisely matching
each RNA medicine
to disease biology

To treat or prevent disease effectively, each RNA therapy must match the biological demands of the disease, including what protein is needed, how long it should act, and where it needs to go.

We design each therapy across three key dimensions:

Protein Expression

Which proteins will drive a therapeutic response?
We translate biological insights into targeted expression strategies by designing RNA medicines to produce the right proteins to modulate disease.

Durability

How long should the therapeutic effect last?
We optimize the half-life of the proteins to achieve the desired duration of action for each indication.

Delivery

Which cells or tissues must the therapy reach?
We engineer delivery systems to guide RNA payloads to the right targets, maximizing precision and therapeutic impact.

By tuning these three dimensions, we aim to create immune-modulating therapies that can be administered in standard care settings, expanding the options for treating complex conditions with long-lasting benefits – all without the burden of cell harvesting, lab manipulation, or inpatient regimens.

 

Our Collection of
State-of-the-Art Technologies

Together with our team’s deep expertise, we draw from a purpose-built, integrated platform of established and emerging RNA technologies, selecting the right tools to engineer programmable RNA medicines tailored to each disease.

Our proprietary platform combines RNA design, delivery systems, data science, and automation to advance therapies with precision, durability, and flexibility.

Circular RNA
Circular RNA
Single-stranded RNA in the form of a closed continuous loop.
We select from multiple proprietary circularization technologies and an extensive IRES library to optimize protein expression and duration of expression.
Linear mRNA
Linear mRNA
Single-stranded RNA.
Our linear mRNAs are engineered using tools that increase and stabilize mRNA half-life and improve translational efficiency, as well as leverage novel chemistries to enhance durability and increase protein expression.
Lipid Nanoparticles (LNP)
Lipid Nanoparticles (LNP)
Spherical vesicles of lipids (including ionizable lipids) to protect and carry RNA to its proper destination in the body.
We have developed a proprietary library of lipids and cell- and tissue-targeted LNPs to optimize delivery of RNAs.
Virus-like Particles (VLP)
Virus-like Particles (VLP)
Nanoscale vesicles composed of viral proteins to protect and carry RNA to its proper destination in the body.
Our library of VLP technologies includes wild-type and targeted VLPs that are complementary to our targeted LNPs.
Machine Learning
Machine Learning
Development and application of software to support discovery efforts.
We deploy artificial intelligence, machine learning, data analytics, and automation to accelerate design and test cycles and optimize RNA medicines at the expression and delivery levels.
Protein Engineering
Protein Engineering
Design and optimize new or modified proteins to achieve desired functions.
Our team has a depth of experience and tools that enable protein engineering design and structural prediction.
 
 
 

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